Chemoselective reactions for the synthesis and application of functional proteins

In 2012 chemists, biochemists and biophysicists from all over Germany started the interdisciplinary research association "Priority Program 1623 / Schwerpunktprogramm 1623". One of the main goals is the development of innovative methods for the synthesis of proteins with exceptional biological importance, in particular by combining chemical and molecular biological approaches.

Hereby, the priority program focuses on the generation of functional proteins like glycoproteins, histones and other proteins that play an important role in signal transduction. To elucidate the functional behavior of these proteins, they will be further modified by the addition of natural posttranslational modifications or biophysical probes. To achieve this goal, conventional molecular biological methods need to be complemented with chemical approaches.

The program combines the expertise of international prestigious scientists that are spread all over Germany to a cooperative interdisciplinary network. This approach results in beneficial synergies that will enable the participating scientists to create new impulses for the development of new methods, address urgent but complicated biological questions and finally strengthen this important research area with the help of leading research groups from Germany.

The projects

First funding period
(2012 - 2015)

Second funding period
(2016 - 2018)