Projects 2012 - 2015 (1st funding period)

In the first funding period, the following projects were funded by the DFG:

Annette Beck-Sickinger, Oliver Seitz
Selective bioconjugation of proteins in live cells via peptide-directed acyl and alkyl transfer reactions

Frank Bordusa
Semisynthesis of antibody drug conjugates via biocatalysis

Alexander Bürkle, Andreas Marx
Targeted poly(ADP-ribosyl)ation of proteins (Gezielte Poly(ADP-Ribosyl)ierung von Proteinen)

Maria Cristina Cardoso, Christian Hackenberger, Heinrich Leonhardt
Site-specific functionalization of nanobodies: From labeling to cellular uptake

Ulf Diederichsen, Harald Kolmar
Chemoselective Reactions for the Synthesis and Application of Functional Proteins

Wolfgang Fischle, Dirk Schwarzer
Establishing a Chemical Tool Box for Modified Nucleosomes and its Application for Analysis of the Histone Code

Bengt Christian Hedberg, Aymelt Itzen
Etablierung einer neuartigen kovalenten enyzmatischen Proteinmarkierungsstrategie durch reversiblen Transfer von CDP-Cholin-Analoga

Stefan Kubick, Stefan Schiller
Reconstitution of tyrosine kinase signaling in cell-free systems: Synthetic membrane protein dimerization and lipid modification

Edward A. Lemke, Carsten Schultz
Spezifische Markierung von Proteinen in lebenden Zellen mit Aminosäurepräzision durch genetisch kodierte Click Chemie

Henning Mootz
New approaches for the site-selective chemical modification of therapeutic proteins under mild conditions

Christof Niemeyer, Frank Schulz
Chemoselective DNA conjugation of proteins to study multienzyme complexes

Marina Rubini
Co- and post-translational engineering of the therapeutic protein Erythropoietin with non-natural amino acids

Daniel Summerer
Verbesserte, programmierbare Genomblockierung mit genetisch kodierten, DNA-interkalierenden Repressormodulen

Robert Tampé
Cellular Logistics - 'Traceless' protein modification by small high-affinity tags

Carlo Unverzagt
Semisynthesis of natural glycoforms of human erythropoietin

Daniel Varón Silva
New Methods for the Synthesis of glycosylphosphatidylinositol anchored proteins with therapeutic applications

Valentin Wittmann
Exploiting Diels-Alder Reactions with Inverse Electron Demand for Bioorthogonal Labeling of Alkene-Substituted Fucosylated Glycoproteins in Cells

Richard Wombacher
Protein labeling in living cells - A combination of enzyme mediated peptide labeling and inverse electron demand Diels-Alder cycloaddition

Yaowen Wu
Untersuchung der Formation von Autophagosomen durch semisynthetische LC3-Protein